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The primary mechanism involves mimicking the action of naturally occurring GLP-1 , a hormone released by the intestine after eating

By demonstrating that peripheral MC1R antagonist administration blocks tanning without affecting pro-sexual behaviour, and central MC4R antagonist administration blocks pro-sexual effects without affecting melanogenesis

Nutrients, 12(3), 870

Following 24, 48, 72, or 96 h after seeding, the medium was supplemented with 10 L of CCK-8 reagent (Beyotime) and the cells were incubated at 37 C for 2 h