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At 48 weeks, weight loss was dose-dependent: the 12 mg group achieved approximately 24.2% mean weight loss, which was meaningfully higher than the approximately 15% reported for semaglutide 2.4 mg in the STEP 1 trial and approximately 20-22% for tirzepatide in the SURMOUNT trials

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Coupled with its specific receptor GLP-1 receptor (GLP-1R), GLP-1/GLP-1R signaling protects pancreatic -cells through AMPK/mTOR, PI3K, and Bax (Huang et al., 2017)