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Consistent with these results, ZnT8 was significantly upregulated and showed clear co-localization with INS + GCG + cells, with higher ZnT8 intensity in INS + GCG + cells than in INS + GCG cells (Supplementary information, Fig

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For instance, HMGB1 can regulate calcium levels through a TLR4/ROS-dependent pathway, leading to calcium leakage from the sarcoplasmic reticulum, a reduction in the amplitude of calcium transients, and decreased cardiomyocyte contractility, which can further aggravate the pathological processes in the heart [307]

Another critical consideration is the etiological difference between MASLD and ALD when targeting NAD + therapeutically