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Thus, short-term activation of GH-RH receptors by GH-RH agonists in vitro leads to stimulatory effects, but chronic, long-term, persistent exposure to these ligands produces a downregulation of receptors and inhibitory effects 58,67

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THE HYPOTHALAMO-PITUITARY INTERFACE The hypothalamus and pituitary serve as the bodys primary interface between the nervous system and the endocrine system

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Like other viruses, COVID-19 might damage pancreatic cells that produce insulin, thus triggering T1DM mainly in children and young people [179, 180]