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The reversible reduction of GSSR substrates usually requires only the first active-site cysteinyl residue and is therefore catalyzed by a monothiol mechanism with ping-pong bi-bi kinetic patterns (Fig

Methylation changes in the Tau , particularly at CpG dinucleotide sites, have been shown to alter microtubule function, promoting aberrant Tau aggregation and the formation of neurofibrillary tangles (130, 131)