Karyopherin alpha2 (Acetyl Lys22) Rabbit Polyclonal Antibody, 50ul Lysosome These proteins play a role

These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II

Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner

while it represses expression of KLF1

The upstream stimulatory factor 2 can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs and is involved in regulating multiple cellular processes

although it partially localizes in the nucleus

Karyopherin alpha2 (Acetyl Lys22) Rabbit Polyclonal Antibody, 50ul Lysosome These proteins play a roleThe import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy independent docking of the protein to the nuclear envelope and the second is an energy dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in