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We furthermore thank Luise Krauth-Siegel for helpful discussions and Tobias Dick and Bruce Morgan for reading an initial version of the manuscript and suggestions

The main incretin hormones secreted by the epithelial cells of the gastrointestinal track are glucagon-like peptide-1 (GLP)-1 and glucose-dependent insulinotropic peptide, also known as Gastric Inhibitory Polypeptide (GIP), which stimulate the pancreatic cells ( and cells) and regulate insulin secretion with respect to blood glucose concentration (Drucker, 2006)