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However, there are also quite different understandings available: applying the fluorescent situ hybridization method (FISH) using 16S rRNA-targeted oligonucleotide probes, some authors suggest that colonic microbes are not in close contact with the mucosa and no significant differences exist between the colonic biopsies and faecal samples (13)

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However, since these data are derived from an animal model, it remains necessary to confirm these effects in humans before considering a clinical application

[DOI] [PubMed] [Google Scholar] 30.Lee J., Hong S.W., Chae S.W., Kim D.H., Choi J.H., Bae J.C., Park S.E., Rhee E.J., Park C.Y., Oh K.W., et al