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Indeed, the combined use of these medications is suggested to be synergistic and, as reported in a recent meta-analysis, superior outcomes with the addition of a GLP-1 RA to SGLT2i can be observed in type 2 diabetes, although observations of cardiovascular and mortality outcomes are limited [29]

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Other examinations, such as computed tomography scan and esophageal manometry, could be helpful in treatment planning, but they are not mandatory [1,4]

Lentiviral infection was performed as described previously (Moura-Alves et al., A similar protocol was used to generate the THP-1 Control and THP-1 AhR-Knockdown (KD) cell lines