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Decades of research have highlighted the clinical demerits of abnormally high body weight (BW), with BMIs exceeding 30 kg/m 2 and 40 kg/m 2 correlated with decreased life expectancies of three and 10 years, respectively

Free mtDNA acts as an endogenous damage-associated molecular patterns (DAMPs) recognized by pattern-recognition receptors (PRRs), triggering inflammatory responses

Wearable health technologies are also useful in real-time tracking of physiological data such as sleep quality, respiratory rate, and physical activities

11 Study limitations and future prospects The research findings to date on the effects of KD on the skin indicate potential benefits

Methods Experimental animals The study was conducted using male TPH1 knockout mice and wild-type C57BL/6 mice (46 weeks, 2126 g) (Animal Feeding Center of Xi'an Jiaotong University Health Science Center)