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For example, 0.5 mg equals 20 units at 2.5 mg/mL but only 10 units at 5 mg/mL

p = 0.048)

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Because SAM is also required for many other methylation reactions, including gene-expression regulation, high NNMT activity draws heavily on SAM and is associated in studies with reduced NAD, a coenzyme central to cellular energy production

However, the mechanism by which Hcy damages the endothelium is still not fully understood