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Before making the diagnosis of PFIC, in the paediatric population, other cholestasis disorders should always be considered in the differential diagnosis, including biliary atresia, choledochal malformations, congenital endocrine disorders, inborn errors of metabolism (mainly during the neonatal period) as well as autoimmune liver diseases, drug-induced cholestasis and other genetic diseases in older children [72]

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492 Myocardiac I/R induces an increase in non-heme iron and increases transcription of FTL and FTH, indicating iron overload in ischemic myocardium

Protein and resistance training matter here, and well get to that next