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Simone Braca at the University of Naples Federico II, explored whether GLP-1 agonists, primarily used for diabetes and weight management, could effectively reduce migraines

This gradual approach is essential, as it helps minimize potential adverse reactions, which are predominantly gastrointestinal and affect about 50% of users

Seidler 2004)

However, Eli Lilly released promising trial results in March, claiming patients lost an average 28 percent of their weight over 80 weeks while on the drug, approaching the effectiveness of far more invasive bariatric surgery