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South Orange, NJ: 2006

In LKB1-deficient non-small cell lung cancer (NSCLC) models, AMPK inactivation derepresses CPS1, whose silencing induces nucleotide pool imbalance (reduced pyrimidine/purine ratio), S-phase arrest, and DNA damage, mechanisms hypothesized to operate in PCa, where ammonium metabolism inhibitors (e.g., targeting glutaminase) combined with autophagy modulators (e.g., ULK1 activators) could exploit metabolic vulnerabilities targeting tumor cells (200)

It is important to be aware that ICU patients may have several risk factors for depletion of glutathione stores and in fact that critical ilness [13] and sepsis [14] may themselves be associated with reduced glutathione

Harris research specialties include somatic stem cells and aging, melanocyte stem cells, and mouse models of hair graying

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