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GHK-Cu is appealing precisely because it addresses the first without aggravating the second

Front Vet Sci 11:1451516 Spnola MP, Mendes AR, Prates JAM (2024b) Chemical composition, bioactivities, and applications of Spirulina ( Limnospira platensis ) in food, feed, and medicine

Without its signal sequence, AP accumulates in the cytoplasm, and only a tiny fraction is exported to the periplasm (Eben and Imlay, 2023)

& Fimognari, C

Although pore and leak pathway permeabilities may be increased at sites without epithelial damage, these cannot typically be measured, as their impact is masked by the large changes in unrestricted pathway permeability and, as a result of sieving properties, much greater increases in flux of creatinine and 4 kDa dextran across the unrestricted pathway