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It plays a key role in glucose and appetite regulation by: Stimulating insulin release (glucose-dependent) Suppressing glucagon secretion Slowing gastric emptying Increasing satiety and reducing appetite In people with type 2 diabetes, this GLP-1 response is impaired leading to poor glycemic control

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Interestingly, the medications that may be the most effective at achieving the desired outcome can be the ones that are more likely to cause adverse effects

Glucagonlike peptide 1-based therapies and risk of hospitalization for acute pancreatitis in type 2 diabetes mellitus: a population-based matched case-control study

Contact your GP or prescribing clinician if : Leg cramps are severe, persistent, or worsening despite hydration and dietary adjustments You experience difficulty walking or performing daily activities due to cramping or muscle pain Cramps are associated with other concerning symptoms such as dizziness or palpitations Seek urgent same-day medical assessment if : Cramps are accompanied by significant muscle weakness, swelling, redness, or warmth in one leg, which could indicate deep vein thrombosis (DVT) You experience numbness, tingling, or loss of sensation in your legs, which may suggest nerve involvement Call 999 or go to A&E immediately if : You develop chest pain or sudden shortness of breath (possible pulmonary embolism) You have severe, persistent abdominal pain radiating to the back, with nausea and vomiting (possible pancreatitis) Your GP may wish to perform a clinical assessment and arrange investigations, such as blood tests to check electrolyte levels (sodium, potassium, magnesium, calcium), renal function, and thyroid function, as abnormalities in these areas can contribute to muscle cramps