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Priority was given to original research articles, including meta-analyses of clinical trials, and those most pertinent to the scope of this review

In particular, oxidative stress reduces the uptake of glutamate in astrocytes, a key step in the recycling of glutamate [16]

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The lack of statistically significant reduction in infarct volume, despite a numerical decrease, suggests that DSIPs primary benefit in this model might be more related to functional neurorecovery and neural network plasticity rather than a direct, massive reduction of necrotic tissue [1]