PTTG1/2/3 Polyclonal Antibody, 50ul Gloves reticuloendothelial system
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PTTG1/2/3 Polyclonal Antibody, 50ul Gloves reticuloendothelial systemPituitary tumor transforming 1 is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase promoting complex (APC) substrate that associates with a separin until activation of the APC. PTTG1 product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. PTTG1 contains 2 PXXP motifs, which are required for its transforming
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