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Intracellularly, the cytosolic concentrations of TRX family proteins are much lower compared to that of glutathione (GSH) but significant enough to provide additional reducing capacity to counter intracellular oxidative stress

Inhibition of the system xc GSHGPX4 axis can predispose cells to ferroptosis, while the primary initiation of ferroptosis typically occurs through the accumulation of toxic lipids, as discussed later in the section

Rahaman, K

[DOI] [PubMed] [Google Scholar] 240.Cavalcanti V., Marques M., Do Nascimento W.M., Rocha A.W.D.O., Ferreira I.D.J., Leo D.P., Flix P.H.C., De Oliveira C.M.C