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In some studies, the Thr metabolism-related product -aminobutyric acid (AABA) has been shown to suppress the expression of pro-inflammatory macrophage-related genes and to jointly restrain inflammatory responses through metabolic reprogramming and EZH2-dependent epigenetic regulation, suggesting that the effects of amino acid metabolism on macrophage function may also extend to the level of metabolism-epigenetic coupling (67)

Regulation of energy homeostasis by the NPY system

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Therefore, the two-sided nature of GPx2 depends on the tumor type and stage of disease

230 In high-fat diet-induced MASLD models, naringin improves liver function, reflected by decreased serum ALT and AST levels