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Experimental findings in mouse KD models demonstrate that reduced abundance of specific Clostridium (e.g., Clostridium sensu stricto , Clostridium clusters XIVa ) correlates significantly with vasculitis progression, whereas supplementation with these Clostridium or SCFAs alleviates vascular inflammation by either activating G protein-coupled receptors (GPR43/109A) or inhibiting HDAC activity

Coupling with drugs, fluorescent tracers or various targeting molecules can significantly change the physico-chemical properties and the intracellular fate of the nanocarriers [28, 51]

Regardless of repeated AMT, long-term quality of life and independence may still be compromised

Nova Z, Skovierova H, Calkovska A

The groups were also well separated with no overlap of the 95% confidence regions indicating distinct metabolite differences between the groups