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[5] The authors concluded that survodutide is generally tolerable in people with compensated or decompensated cirrhosis, does not require pharmacokinetic-based dose adjustment for cirrhosis, and may improve liver-related non-invasive tests supporting further investigation for MASH-related cirrhosis while remaining early-stage, small-sample, open-label evidence

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Before sacrifice, mice were anesthetized with ketamine/xylazine followed by lung function measurement and tissue harvesting as previously described 35,62