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Most common (especially in first 4-8 weeks): Nausea Early fullness/satiety Constipation Mild reflux or burping Less common but important: Severe nausea preventing adequate eating or drinking Gallbladder issues (rapid weight loss increases gallstone risk) Pancreatitis (rare, more common with high triglycerides or gallstone history) Dehydration The side effect no one mentions: Undereating

As movement becomes harder, habits tend to change

In this study, we used LLMs to augment this approach for characterizing public perceptions about GLP-1 RAs on Reddit

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JAMA 334 , 10841093 (2025)