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The phase 3 TRIUMPH-4 data showed these rates at 9 mg and 12 mg doses respectively: Nausea: 38.1% and 43.2% (vs 10.7% placebo) Diarrhea: 34.7% and 33.1% (vs 13.4% placebo) Constipation: 21.8% and 25.0% (vs 8.7% placebo) Vomiting: 20.4% and 20.9% (vs placebo) These numbers are higher than cagrilintide monotherapy across the board

B12 offers the possibility of halting or even reversing progression and the tablets are affordable, certainly when you consider the cost, in every sense of the word, of living with a progressive condition that just gets worse over time

American Journal of Physiology-Endocrinology and Metabolism

A common protocol for patients with a B12 deficiency may be 1,000 mcg daily for one week, then the same dosage once weekly, and then the same dosage once per month after the deficiency has been addressed

In conclusion, while the future of ED treatments looks promising with these innovative therapies, it's crucial to remember that many are still in the nascent stages of research