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If you regularly monitor your heart rate and notice sustained elevations above this threshold, particularly if this represents a significant change from your baseline, discuss this with your healthcare provider

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Type 1 diabetes is the most critical contraindication

TNF- can induce synovial cells to express intercellular adhesion molecule-1 (ICAM-1), making it easier for immune cells to adhere and transmigrate across endothelial cells into the synovium (147)