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It is associated with a wide range of clinical complications, such as cardiovascular diseases (e.g., ischemic heart disease and heart failure), metabolic disorders like type 2 diabetes, dyslipidemia, metabolic dysfunction-associated steatotic liver disease, obstructive sleep apnoea syndrome, knee osteoarthritis, mental health disorders, and certain types of cancer [2, 3]

Although these medications mimic a natural human process, they do have side effects and important contraindications to consider

The current study represents the first systematic investigation of the pregnenolone sulfating activity of SULT2B1a allozymes, including their substrate affinity compared to the wild-type enzyme

[282] demonstrated that transitioning from a Western dietary pattern to a Mediterranean diet, while maintaining consistent energy intake, macronutrient distribution, and levels of physical activity, significantly influences individual clinical outcomes, as well as the gut microbiome and metabolome, after a four-week intervention period in a population exhibiting cardiometabolic risk associated with an unhealthy lifestyle [282]

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