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While initial clinical observations indicate promising effects in specific conditions such as diabetic peripheral neuropathy, irritable bowel syndrome, and idiopathic intracranial hypertension, rigorous clinical trials are needed to confirm their efficacy, elucidate weight-loss-independent mechanisms, and establish comprehensive safety profiles across various pain conditions

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Looking ahead, what might be next for this research

When prolactin is abnormally high for a prolonged period of time, it can cause hypogonadism, loss of libido, depressed mood, reduced bone density, and muscle wasting [31, 32]

External microbiomes, like those in sediment, are typically more influenced by environmental factors than host-associated microbiomes [63]