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The recognition that thrombotic occlusion of a coronary artery results in a wavefront of irreversible myocardial cell injury extending from the subendocardium to the subepicardium in a time-dependent fashion led to the introduction of reperfusion therapy for myocardial infarction.1 However, restoration of blood flow to previously ischemic myocardium results in the so-called ischemia/reperfusion (I/R) injury.2 The I/R combination causes numerous and collateral reactions in tissues, culminating in the alteration of essential molecules and organelles in a number of cells including components of the coronary endothelium and myocardium with the recruitment of circulating blood elements, eg, leukocytes and platelets

Intrathecal injection of allogenic bone marrow-derived mesenchymal stromal cells in treatment of patients with severe ischemic stroke: Study protocol for a randomized controlled observer-blinded trial

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Response from industry However, Eli Lilly hit back, criticising the reports accuracy

Stable isotope dilution mass spectrometry quantification of hydrogen sulfide and thiols in biological matrices