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This natural increase in activity creates a positive feedback loop, further strengthening heart health

Activation of GLP-1 receptors in cortical arterioles enhances cerebral blood flow and improves perfusion, which may promote neuroprotection against ischemic stroke [44]

As for the effects of chronic fat intake on GIP secretion, the expression of regulatory factor X 6 (Rfx6) and pancreatic and duodenal homeobox 1 (Pdx1), important transcription factors involved in GIP expression [67-69], was found to be increased in GIP-producing cells in high-fat diet (HFD)-induced obese mice, suggesting a possible mechanism for GIP hypersecretion in obesity [68, 70]

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