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Supplementary information Supplementary Table 1 (download DOCX Sample sizes and statistical details for all figures and Extended Data figures

Circumstance: Starting GLP-1 medications Suggested interval: Baseline, then every 36 months Circumstance: Stable diabetes management Suggested interval: Every 6 months Circumstance: Poor diabetes control Suggested interval: Every 3 months Circumstance: General health screening Suggested interval: Annually Why early detection matters Regular monitoring enables early detection of medication side effects, treatment resistance, or developing complications before symptoms appear