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A controlled trial of homocysteine lowering and cognitive performance

This comparison shows why the single 10mg vial is favored by experienced users who prefer preparation flexibility

Nestler EJ, Pea CJ, Kundakovic M, Mitchell A, Akbarian S

PIONEER 7 was a 52-week open-label trial that compared the efficacy and safety of once-daily oral semaglutide (with flexible-dose adjustment based on prespecified HbA1c and tolerability criteria to approximate treatment individualization in clinical practice) with the DPP-4 inhibitor sitagliptin, as an add-on to existing glucose-lowering medication (one or two oral antidiabetic agents, i.e., metformin, sulphonylureas, SGLT-2 inhibitors or thiazolidinediones), in patients with T2DM

Sorli C, Harashima SI, Tsoukas GM et al (2017) Efficacy and safety of once-weekly semaglutide monotherapy versus placebo in patients with type 2 diabetes (SUSTAIN 1): a double-blind, randomised, placebo-controlled, parallel-group, multinational, multicentre phase 3a trial