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Specifically, TAMs sustain stemness via direct activation of SHH pathway in colon cancer (213), meanwhile SHH alternative signaling pathways are TAM-induced in pancreatic cancer (TGFB1/SMAD2/SMAD3/NANOG pathway) (215), in liver cancer (via the NOTCH pathway) (216), breast cancer (via the SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase (SRC) pathway) (196), and in glioma via extracellular regulated kinase 1/2 (ERK1/2) pathway (217)

Mechanistic studies have elucidated the process by which excessive iodine intake disrupts thyroid homeostasis and triggers autoimmunity

Inhibition of NF-kappaB signaling pathway by resveratrol improves spinal cord injury

Funding This work was supported by the Japan Agency for Medical Research and Development (grant numbers 20ak0101088h0003, 21ak0101153h0001) and JST SPRING (grant number JPMJSP2110)

However, patients with advanced BTC still have a poor prognosis, with a median survival of 0.05)