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May relate to blood pressure effects in sensitive individuals

The character Red Rackham was based on the Golden Age of Piracy pirates John Rackham, Blackbeard, and Montbars the Exterminator

Unlike traditional treatments that increasing blood pressure which can have potential side effects on cardiovascular health, PT-141 works as a melanocortin receptor agonist, specifically activating MC3R and MC4R receptors in areas of the brain