GPR114 Polyclonal Antibody, 20ul Bottles Represses ligand-dependent transcriptional activation function

Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed: 25661920)

The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors

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Three transcript variants have been identified for this gene

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GPR114 Polyclonal Antibody, 20ul Bottles Represses ligand-dependent transcriptional activation functionADGRG5 encodes a member of the adhesion family of G protein coupled receptors. Members of this family are characterized by long N termini and multiple functional domains. They may play a role in the immune system as well as in the central nervous system. Alternative splicing results in multiple transcript variants.