p53 Polyclonal Antibody, 20ul[BT-AP06825] Recombinant Protein Expression Several transcript variants encoding two

Several transcript variants encoding two different isoforms have been found for this gene

Negative regulator of ubiquitin like proteins 1 interacts with the product of the AIPL1 gene

and represses their transcriptional activity

These proteins make up a major component of the basement membrane and have been implicated in a wide variety of biological processes including cell adhesion

It is required for N-glycan trimming to Man5-6GlcNAc2 in the endoplasmic-reticulum-associated degradation pathway

p53 Polyclonal Antibody, 20ul[BT-AP06825] Recombinant Protein Expression Several transcript variants encoding twoTP53 encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The tumor protein p53 responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li Fraumeni syndrome.