Raf-1 Polyclonal Antibody, 100ul[BT-AP13533] Polyclonal Antibodies Knockout studies in mice suggested

Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure

This domain is found in proteins encoded by the TCEAL elongation factor (transcription elongation factor A (SII)-like) gene family also located on the X chromosome

This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit

These variants encode different isoforms| which are differentially expressed and have different kinase activities

Raf-1 Polyclonal Antibody, 100ul[BT-AP13533] Polyclonal Antibodies Knockout studies in mice suggestedThis gene is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2.