PXR Polyclonal Antibody, 50ul Lysosome 25- dihydroxyvitamin D3) receptor) encodes

25- dihydroxyvitamin D3) receptor) encodes the nuclear hormone receptor for vitamin D3

The gene maps to the region on chromosome 22q11

|tissue specificity:Expressed in monocytes and mature macrophages such as Kupffer cells in the liver| red pulp macrophages in the spleen| cortical macrophages in the thymus| resident bone marrow macrophages and meningeal macrophages of the central nervous system

In receptor-expressing cells

Translocates from cytoplasm to nucleus under dexamethasone induction

PXR Polyclonal Antibody, 50ul Lysosome 25- dihydroxyvitamin D3) receptor) encodesThis gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand binding domain and a DNA binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9 cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including