Rat Mesencephalic Astrocyte-derived Neurotrophic Factor, MANF ELISA Kit, 96T Filtration It is an activator of

It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo

A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis

it accurately replicates UV-damaged DNA

In addition to histone acetylation

integrin-mediated signal transduction

Rat Mesencephalic Astrocyte-derived Neurotrophic Factor, MANF ELISA Kit, 96T Filtration It is an activator ofSelectively promotes the survival of dopaminergic neurons of the ventral mid brain (By similarity). Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra (PubMed: 16462600). Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (PubMed: 16462600). Inhibits cell proliferation and endoplasmic reticulum (ER) stress induced cell death (By similarity). Retained in the ER