Shc(Phospho Tyr427) Polyclonal Antibody, 100ul Monoclonal Antibody Preparation The protein encoded by this

The protein encoded by this intronless gene is found in the nucleus| where it can inhibit DNA synthesis and promote S phase arrest coupled to apoptosis

and behaves as a direct c-Myc target gene

This forms the basis of many overlapping biological activities of IL15 and IL2

In mitosis RCC1 is phosphorylated at Ser11

YEATS4 has been shown to be amplified in tumors

Shc(Phospho Tyr427) Polyclonal Antibody, 100ul Monoclonal Antibody Preparation The protein encoded by thisThis gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2 SOS complex. p66Shc is not involved in Ras activation.