APBB3 Rabbit Polyclonal Antibody, 20ul Electrophoresis & Labeling The protein encoded by this

The protein encoded by this gene belongs to the Fbxs class and| as a transcriptional target of the tumor protein p53| is thought to be involved in degradation of specific proteins in response to p53 induction

The protein binds to and negatively regulates signalling by transforming growth factor beta (TGF-beta)

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Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome

Mutations in this gene are predicted to result in neurogenic defects

APBB3 Rabbit Polyclonal Antibody, 20ul Electrophoresis & Labeling The protein encoded by thisThe protein encoded by this gene is a member of the APBB protein family. It is found in the cytoplasm and binds to the intracellular domain of the Alzheimer's disease beta amyloid precursor protein (APP) as well as to other APP like proteins. It is thought that the protein encoded by this gene may modulate the internalization of APP. Multiple transcript variants encoding several different isoforms have been found for this gene.