GNA13 Polyclonal Antibody, 20ul Vacuum Filter Defects in this gene do

Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged

N-terminal part of this PTP contains two tandem Src homolog (SH2) domains| which act as protein phospho-tyrosine binding domains| and mediate the interaction of this PTP with its substrates

The encoded protein may also play a role in synaptic maturation during cortical development

Two transcript variants

Transcript variants utilizing alternative polyA_signal have also been noted in literature

GNA13 Polyclonal Antibody, 20ul Vacuum Filter Defects in this gene doGuanine nucleotide binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.,PTM: Palmitoylation is critical for proper membrane localization and signaling.,PTM: Phosphorylation on Thr 203 by PKA destabilizes the heterotrimer of alpha, beta and gamma, and inhibits Rho activation.,Belongs to the G alpha family. G(12) subfamily.,subcellular location: Identified by mass spectrometry in melanosome