P53 (Mono Methyl Lys370) Monoclonal Antibody(Q59), 20ul Culture Plate Inserts SEMA3A is a member of

SEMA3A is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain

It is a mediator of mitochondrial damage induced by caspase-8 (CASP8)| CASP8 cleaves this encoded protein

Alternative splicing generates multiple transcript variants encoding distinct isoforms

Mutations in this gene are associated with hereditary pancreatitis

identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif

P53 (Mono Methyl Lys370) Monoclonal Antibody(Q59), 20ul Culture Plate Inserts SEMA3A is a member ofThis gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li Fraumeni syndrome.