Presenilin 1 Polyclonal Antibody, 50ul Biomatrix Alternatively spliced transcript variants encoding

Alternatively spliced transcript variants encoding different isoforms have been described for GFRA4

This protein may also function as a tumor suppressor in some cancers

The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs

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The importance of angiotension II

Presenilin 1 Polyclonal Antibody, 50ul Biomatrix Alternatively spliced transcript variants encodingAlzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease linked mutations result in increased production of the longer form of amyloid beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma secretase, an enzyme that cleaves APP.