Stat2 Polyclonal Antibody, 50ul[BT-AP14536] Cell Transfection A chromosomal aberration involving CRTC1

A chromosomal aberration involving CRTC1 is found in mucoepidermoid carcinomas

Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly

Required for CDT1 proteolysis in response to DNA damage through the CUL4-DDB1 E3 ubiquitin-protein ligase

a stimulator of macroautophagy

and regulation of signaling complexes (reviewed in PMID: 9701547

Stat2 Polyclonal Antibody, 50ul[BT-AP14536] Cell Transfection A chromosomal aberration involving CRTC1The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this