CSKI2 Polyclonal Antibody, 50ul Centrifugal Filter Defects in this gene are

Defects in this gene are a cause of deafness autosomal recessive type 49 (DFNB49)

Mutations in this gene are associated with papillary renal cell carcinoma| hepatocellular carcinoma| and various head and neck cancers

The encoded protein has multiple proposed functions

followed by a glycine-rich C-terminus

The encoded protein has been shown to interact with neurotrophin receptor

CSKI2 Polyclonal Antibody, 50ul Centrifugal Filter Defects in this gene areThis gene encodes a large protein that contains six ankyrin repeats, as well as a Src homology 3 (SH3) domain and two sterile alpha motif (SAM) domains, which may be involved in protein protein interactions. The C terminal portion of this protein is proline rich and contains a conserved region. A related protein interacts with calcium calmodulin dependent serine protein kinase (CASK). Alternative splicing results in multiple transcript variants.