PKR(Phospho Thr451) Polyclonal Antibody, 50ul Protein Post-translational Modification This gene product shows selectivity

This gene product shows selectivity for members of the ERK family of MAP kinases and is localized to the cytoplasm and nucleus

It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets

suggesting that its substrate may carry its own oxygen

The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice

The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases

PKR(Phospho Thr451) Polyclonal Antibody, 50ul Protein Post-translational Modification This gene product shows selectivityThe protein encoded by this gene is a serine threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene.