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Btk Polyclonal Antibody, 100ul[BT-AP01005] Insect Expression subcellular localization

SKU: 17908365015

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Btk Polyclonal Antibody, 100ul[BT-AP01005] Insect Expression subcellular localizationThe protein (Bruton tyrosine kinase) encoded by BTK plays a crucial role in B cell development. Mutations in this gene cause X linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Description

subcellular localization

Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches

possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome

which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy

This gene encodes an alpha 3 subunit

Btk Polyclonal Antibody, 100ul[BT-AP01005] Insect Expression subcellular localizationThe protein (Bruton tyrosine kinase) encoded by BTK plays a crucial role in B cell development. Mutations in this gene cause X linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms.

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