ErbB-3 Polyclonal Antibody, 50ul[BT-AP03041] Drug Development and Evaluation at least one of which

at least one of which undergoes proteolytic processing

CENPL is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al

Overexpression of this gene may play a role in leukemogenesis| and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein

The encoded protein (cadherin 19) is a calcium dependent cell-cell adhesion glycoprotein containing five extracellular cadherin repeats

and is found in either a latent form composed of a mature peptide homodimer

ErbB-3 Polyclonal Antibody, 50ul[BT-AP03041] Drug Development and Evaluation at least one of whichERBB3 encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation