UBE2K Polyclonal Antibody, 20ul Subcellular Fractions Alternatively spliced transcript variants which

Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene

and are involved in a variety of biological processes

Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone

|induction:Regulated by cellular iron levels through binding of the iron regulatory proteins| IRP1 and IRP2| to iron-responsive elements in the 3'-UTR

The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53

UBE2K Polyclonal Antibody, 20ul Subcellular Fractions Alternatively spliced transcript variants whichThe protein encoded by this gene belongs to the ubiquitin conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains