Mouse DNA Topoisomerase 1, TOP1 ELISA Kit, 96T Enzymes This form acts to modulate

This form acts to modulate the activity of the m

Alternative splicing or deletion caused by a translocation event in this paternally-expressed region is responsible for Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure

This gene is highly expressed in the brain and may function as an integrin ligand in the brain

Binds to a consensus sequence in gene promoters (By similarity)

Contains 1 EGF-like domain

Mouse DNA Topoisomerase 1, TOP1 ELISA Kit, 96T Enzymes This form acts to modulateReleases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA (3' phosphotyrosyl) enzyme intermediate and the expulsion of a 5' OH